Yangiliklar tarkibi
Endogen dht (tana tomonidan sintez qilingan) juda qisqa metabolik tsiklga ega. Testosterondan keyin DHT 5 -} Qonda hayotning yarmi 20 daqiqada 20 {{9} {9}- dan iborat. Uning aksariyati jigarda faol bo'lmagan metabolitlarga (masalan anrostandiol) 24 soat ichida chiqariladi. Biroq, shuni ta'kidlash kerakki, dht, soch follikulalari va prostata kabi to'qimalarda retseptorlarga qat'iy bog'laydi. ZHT qonda metabollangandan keyin ham, uning to'qimalarga ta'siri bir necha hafta yoki hatto oylar davomida davom etishi mumkin. Shuning uchun soch to'kilishini uzoq muddatli davolash juda muhimdir.https://www.fiercs.com/ersteroid{22} =psteroid{3}}finiqlik (2) ~premammmmmgütücathalitecatsiyangiz (2))
Dh atmoxogenion (masalan, stanol tayyorgarligi kabi) to'ldirishda ushlab turish vaqti ma'muriyat yo'nalishi bo'yicha sezilarli darajada farq qiladi. Og'zaki preparatlar (masalan, stanol tabletkalari kabi) Jigarda 48 soat davomida 48 soat davom etadigan -} -} -} -} -} 2 soat ichida qon kontsentratsiyasini boshdan kechiradi. Boshqa tomondan, in'ektsion preparatlar (masalan, Stanol Enyansi kabi), ester zanjirining uzoq davom etadigan harakati, uning to'liq harakati, to'liq metabolizm 2-3 hafta davom etadi. Ushbu davrda qon DHT darajasi ko'tarilib, ularni uzoq muddatli tartibga solishni talab qiladigan holatlar uchun mos keladi (masalan, o'ziga xos gormonni almashtirish terapiyasi).
Shaxsiy metabolik farqlar bu "belgilangan muddatni" yengishda asosiy o'zgaruvchi hisoblanadi. In individuals with impaired liver function, due to decreased metabolic enzyme activity, DHT clearance may be prolonged by 50%-100%, increasing the risk of accumulation. Biroq, muntazam ravishda jismoniy mashqlar bilan shug'ullanadigan, jigar metabolik quvvati yaxshilanganligi sababli, DHTni tozalash 15% -20% ga tezlashishi mumkin. Bundan tashqari, yoshi metabolik samaradorlikka ham ta'sir qiladi. O'rta yoshli va keksa erkaklarda 5 -} kamaydi va keksa erkaklar metrizmni kamaytiradi va metabolizmni sekinlashtiradi va natijada uzoq vaqt ushlab turiladi.
Endocrinologists point out: "The key to paying attention to DHT's retention time in the body is to understand the difference between 'immediate metabolism' and 'long-term effects.' DHT may disappear quickly from the blood, but its effects on tissues are persistent. Therefore, whether treating hair loss or regulating hormones, a plan must be formulated in accordance with metabolic laws, rather than focusing solely on the short-term retention time of the drug."
